Volume 41, Issue 2 p. 435-443
Article
Free Access

Effect of 5-fluorouracil on liver regeneration and metabolism after partial hepatectomy in the rat

Naofumi Nagasue MD

Corresponding Author

Naofumi Nagasue MD

Second Department of Surgery, Kyushu University School of Medicine, Fukuoka 812, Japan

Instructor.

Second Department of Surgery, Kyushu University Hospital, Fukuoka 812, Japan===Search for more papers by this author
Michio Kobayashi MD

Michio Kobayashi MD

Second Department of Surgery, Kyushu University School of Medicine, Fukuoka 812, Japan

Associate Professor.

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Atsushi Iwaki MD

Atsushi Iwaki MD

Second Department of Surgery, Kyushu University School of Medicine, Fukuoka 812, Japan

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Hirofumi Yukaya MD

Hirofumi Yukaya MD

Second Department of Surgery, Kyushu University School of Medicine, Fukuoka 812, Japan

Senior Resident

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Ryoichi Kanashima MD

Ryoichi Kanashima MD

Second Department of Surgery, Kyushu University School of Medicine, Fukuoka 812, Japan

Senior Resident

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Kiyoshi Inokughi MD, PhD

Kiyoshi Inokughi MD, PhD

Second Department of Surgery, Kyushu University School of Medicine, Fukuoka 812, Japan

Professor.

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Abstract

The effects of 5-fluorouracil (5-FU) on regenerating liver were studied after two thirds hepatectomy in rats. In Group I, 68% hepatectomy was performed. In Group II, 5-FU in a dose of 20 mg/kg was administered intravenously immediately after, 24 and 48 hours after the same hepatectomy. In Group III, the same amount of 5-FU was given after sham-operation. The mortality rates were 4.5% in Group I, 28.0% in Group II, and 0% in Group III. The treatment with 5-FU following hepatectomy caused not only suppression but delay of liver cell division. Histologic changes such as cellular degeneration, liver steatosis and dilatation of the sinusoidal space were marked and prolonged in the hepatectomy-5-FU group. The metabolic abnormalities in albumin, cholesterol, triglycedides, and phospholipids were further more profound in Group II compared to those in Group I. In Group III, moderate derangements in albumin, triglycerides and phopholipids were observed. The results may indicate that adjuvant chemotherapy with 5-FU or similar drugs immediately after partial hepatectomy in hepatoma patients should be performed with great care if necessary. Otherwise, it should not be carried out until hepatic regeneration is almost completed.